PXD001792-2

PXD001792 is an original dataset announced via ProteomeXchange.

Title	High-throughput phosphoproteomics reveals in vivo insulin signaling dynamics
Description	In this project we report 133 biologically distinct mouse liver cell (Hepa 1-6 and FL83B) and mouse tissue (brain, kidney, and liver) phosphoproteomes prepared using a newly developed scalable, single-run phosphoproteomics platform, using titanium dioxide (TiO2) based phosphopeptide enrichment and performed in 96-well format. We combine this technology with in situ hepatic stimulation, to generate time-resolved maps of insulin signaling in the mouse liver.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:22:19.556.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mario Oroshi
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2015-02-09 01:02:32	ID requested
1	2015-08-19 08:41:30	announced
⏵ 2	2024-10-22 04:22:24	announced	2024-10-22: Updated project metadata.

10.1038/nbt.3327;

Humphrey SJ, Azimifar SB, Mann M, High-throughput phosphoproteomics reveals in vivo insulin signaling dynamics. Nat Biotechnol, 33(9):990-5(2015) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: Mouse, Brain, Kidney, Q Exactive, Liver, Phosphoproteome

Matthias Mann
contact affiliation	Dept. Proteomics and Signal Transduction Max-Planck Institute of Biochemistry
contact email	mmann@biochem.mpg.de
lab head
Mario Oroshi
contact affiliation	Proteomics
contact email	oroshi@biochem.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2015/08/PXD001792

PRIDE project URI

• PRIDE
  1. PXD001792
     1. Label: PRIDE project
     2. Name: High-throughput phosphoproteomics reveals in vivo insulin signaling dynamics