⮝ Full datasets listing

PXD001681-2

PXD001681 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHA-mSLX4 wild type and SIMdependent interactors
DescriptionSUMOylation is known to play important roles in the DNA damage response, however, a role for SUMOylation in interstrand crosslink repair remains enigmatic. We report on the regulation of the SLX4 nuclease scaffold protein by SUMOylation. SLX4 contains three SUMO-Interaction Motifs (SIMs). Mutating all three SIMs abrogated the binding of SLX4 to SUMO-2 and covalent SLX4 SUMOylation. We attempt to identify which protein interaction are SIM dependent.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:22:36.882.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterRomán González-Prieto
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue; acetylated residue; monohydroxylated residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02015-01-15 01:55:22ID requested
12015-03-02 06:52:01announced
22024-10-22 04:22:44announced2024-10-22: Updated project metadata.
Publication List
Gonz, á, lez-Prieto R, Cuijpers SA, Luijsterburg MS, van Attikum H, Vertegaal AC, SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites. EMBO Rep, 16(4):512-9(2015) [pubmed]
Keyword List
curator keyword: Biological, Biomedical
submitter keyword: DNA Repair,SLX4, Fanconi Anemia, SUMO, Ubiquitin
Contact List
Alfred C O Vertegaal
contact affiliationDepartment of Molecular Cell Biology, Leiden University Medical Center, Leiden, the Netherlands.
contact emailA.C.O.Vertegaal@lumc.nl
lab head
Román González-Prieto
contact affiliationAndalusian Center for Regenerative Medicine and Cell Biology, CABIMER, University of Seville
contact emailR.Gonzalez_Prieto@lumc.nl
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2015/03/PXD001681
PRIDE project URI
Repository Record List
[ + ]