PXD001048-1

PXD001048 is an original dataset announced via ProteomeXchange.

Title	Proteomic profiling of melanoma progression
Description	Melanoma is one of the most aggressive malignancies. It is the second most common tumor in patients at the ages of 20-35 with increased prevalence in western countries. Patient prognosis largely depends on the tumor stage upon diagnosis, which is determined based on the depth of the primary tumor, ulceration and metastases. To date, only a few studies profiled melanoma proteomes. Here we assembled a panel of nine cell lines, including two melanocyte cultures, two cell lines originating from primary tumors, and five cell lines from metastatic lesions. We identified in total more than 9,000 proteins, and identified the processes that change during melanoma progression. Finally we identified three novel prognostic markers of melanoma overall survival.
HostingRepository	PRIDE
AnnounceDate	2020-06-12
AnnouncementXML	Submission_2020-06-11_23:27:00.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tamar Geiger
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2014-06-09 07:04:12	ID requested
⏵ 1	2020-06-11 23:27:01	announced
2	2024-10-22 05:07:16	announced	2024-10-22: Updated project metadata.

Harel M, Ortenberg R, Varanasi SK, Mangalhara KC, Mardamshina M, Markovits E, Baruch EN, Tripple V, Arama-Chayoth M, Greenberg E, Shenoy A, Ayasun R, Knafo N, Xu S, Anafi L, Yanovich-Arad G, Barnabas GD, Ashkenazi S, Besser MJ, Schachter J, Bosenberg M, Shadel GS, Barshack I, Kaech SM, Markel G, Geiger T, Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence. Cell, 179(1):236-250.e18(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: melanoma, melanocytes, cancer, Q-Exactive, label-free quantification

Tamar Geiger
contact affiliation	Department of Human Molecular Genetics and Biochemistry Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel
contact email	geiger@post.tau.ac.il
lab head
Tamar Geiger
contact affiliation	Tel Aviv University
contact email	geiger@post.tau.ac.il
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/06/PXD001048

PRIDE project URI

• PRIDE
  1. PXD001048
     1. Label: PRIDE project
     2. Name: Proteomic profiling of melanoma progression