PXD000679-1

PXD000679 is an original dataset announced via ProteomeXchange.

Title	A Pilot Proteomic Study of Protein Markers in Autism Spectrum Disorder
Description	Autism spectrum disorder (ASD) diagnosis is increasing, with 1/88 children believed to be affected by the disorder, with a most recent survey suggesting numbers as high as 1/50. Treatment and understanding of ASD causes is a pressing health concern. ASD protein biomarkers may provide clues about ASD cause. Protein biomarkers for ASDs could be used for ASD diagnosis, subtyping, treatment monitoring and identifying therapeutic targets. Here we analyzed the sera from 7 children with ASD and 7 matched controls using Tricine gel electrophoresis (Tricine-PAGE) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). Overall, we found increased levels of apolipoproteins (Apos) ApoA1 and ApoA4, involved in cholesterol metabolism and of serum paraoxanase/arylesterase 1 (PON1), involved in preventing oxidative damage, in the sera of children with ASD, compared with their matched controls. All three proteins are predicted to interact with each other and are parts of High Density Lipoproteins (HDLs). Further studies are needed to validate these findings in larger subject numbers.
HostingRepository	PRIDE
AnnounceDate	2022-02-22
AnnouncementXML	Submission_2022-02-22_03:39:33.713.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD000679
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Costel Darie
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q-Tof micro

Revision	Datetime	Status	ChangeLog Entry
0	2014-01-10 00:58:43	ID requested
⏵ 1	2022-02-22 03:39:34	announced

Ngounou Wetie AG, Wormwood K, Thome J, Dudley E, Taurines R, Gerlach M, Woods AG, Darie CC, A pilot proteomic study of protein markers in autism spectrum disorder. Electrophoresis, 35(14):2046-54(2014) [pubmed]

submitter keyword: Autism, ASD, oxidative stress, cholesterol, apolipoprotein, biomarkers

Costel C. Darie
contact affiliation	Department of Chemistry & Biomolecular Science Clarkson University, Potsdam, NY, 13699, Box 5810
contact email	cdarie@clarkson.edu
lab head
Costel Darie
contact affiliation	Chemsitry & Biomolecular Science
contact email	cdarie@clarkson.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD000679
     1. Label: PRIDE project
     2. Name: A Pilot Proteomic Study of Protein Markers in Autism Spectrum Disorder