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PXD051359-1

PXD051359 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTargeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome
DescriptionThe efficacy of immunotherapy against colorectal cancer (CRC) is impaired by insufficient immune cell recruitment into the tumor microenvironment. Our study shows that targeting circDNA2v, a circular RNA commonly overexpressed in CRC, can be exploited to elicit cytotoxic T-cell recruitment. CircDNA2v functions through binding to IGF2BP3, preventing its ubiquitination, and prolonging IGF2BP3 half-life, which in turn sustains the mRNA level of the protooncogene c-Myc. Targeting circDNA2v by gene silencing downregulates c-Myc to concordantly induce tumor cell senescence and the release of proinflammatory mediators. Production of CXCL10 and IL-9 by CRC cells is elicited through JAK-STAT1 signaling, in turn promoting the chemotactic and cytolytic activities of CD8+ T cells. Clinical evidence associates increased circDNA2v expression in CRC tissues with reduction in CD8+ T-cell infiltration and worse outcomes. The regulatory relationship between circDNA2v, cellular senescence and tumor infiltrating lymphocytes thus provides a rationale approach for improving immunotherapy in CRC.
HostingRepositoryiProX
AnnounceDate2024-04-11
AnnouncementXMLSubmission_2024-04-11_01:42:27.351.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterShuang Wu
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF-X
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-04-11 01:41:58ID requested
12024-04-11 01:42:27announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: circular RNA, circDNA2v, IGF2BP3, c-Myc, senescence, CXCL10, IL-9, CD8+T cells
Contact List
Hao Gu
contact affiliationAnhui Medical University
contact emailguhao@ahmu.edu.cn
lab head
Shuang Wu
contact affiliationAnhui Medical University
contact emailwushuang1994326@126.com
dataset submitter
Full Dataset Link List
iProX dataset URI