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PXD051353-1

PXD051353 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleBailixiang tea, an herbal medicine formula, co-suppresses TLR2/MAPK8 and TLR2/NF-κB signaling pathways to protect against LPS-triggered cytokine storm in mice
Descriptionwe aimed to explore the molecular mechanism underlying its effects through blood proteomics and transcriptomics analyses. To achieve this, mice were orally administered BLX for 24 h after being treated with 5 mg/kg lipopolysaccharide (LPS). The results demonstrated that BLX effectively down-regulated the overproduction of interleukin 6 (IL-6) and tumor necrosis factor-α (TNF-α) in both the serum and lung and spleen tissues. Furthermore, BLX effectively mitigated the overproduction of monocyte chemoattractant protein-1 (MCP-1) in the serum. Histopathological observations further confirmed the significant protective effect of BLX treatment against LPS-induced lung and spleen damage. Through comprehensive multi-omics analysis, it was revealed that BLX specifically targeted and regulated TLR2/MAPK8 and LR2/NF-κB signaling pathways, which play a crucial role in the production of key cytokines.
HostingRepositoryiProX
AnnounceDate2024-04-11
AnnouncementXMLSubmission_2024-04-11_00:27:54.817.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterXianyu Li
SpeciesList scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-04-11 00:27:25ID requested
12024-04-11 00:27:55announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Bailixiang tea, lipopolysaccharide, cytokine storm, blood proteomics, transcriptomics, TLR2/MAPK8/NF-κB signaling pathway
Contact List
Xianyu Li
contact affiliationChina Academy of Chinese Medical Sciences
contact emailphd_xianyuli@foxmail.com
lab head
Xianyu Li
contact affiliationChina Academy of Chinese Medical Sciences
contact emailphd_xianyuli@foxmail.com
dataset submitter
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iProX dataset URI