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PXD050360-1

PXD050360 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic analysis of vascular tissue from critical limb ischemia mouse models treated with Etrinabdione
DescriptionVasculogenic therapies have been investigated for the treatment of peripheral artery disease (PAD) with very limited success in clinical trials. The isoform PP2A (protein phosphatase 2)/B55alpha inhibits the activity of the prolyl hydroxylase 2 (PHD2) and activates the hypoxia inducing factor-1alpha (HIF-1alpha), playing a key role in in vessel remodeling. Thus, PP2A/B55alpha activators may have the potential to induce angiogenesis and arteriogenesis. Herein we investigated the pharmacological attributes of VCE-004.8 (Etrinabdione) and its effectiveness in a murine model of critical limb ischemia.
HostingRepositoryPRIDE
AnnounceDate2024-04-03
AnnouncementXMLSubmission_2024-04-03_01:29:10.180.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMartin Garrido
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentBruker Daltonics timsTOF series
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-03-05 06:18:48ID requested
12024-04-03 01:29:10announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Vascular tissue, critical limb ischemia
Contact List
Eduardo Muñoz
contact affiliationMaimonides Biomedical Research Institute of Córdoba (IMIBIC), Córdoba, Spain Cellular Biology, Physiology and Immunology Department, University of Córdoba, Spain Hospital Universitario Reina Sofía, Córdoba, Spain
contact emailfi1muble@uco.es
lab head
Martin Garrido
contact affiliationHeidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Bioquant, Heidelberg, Germany
contact emailmartin.garrido@uni-heidelberg.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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