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PXD047492-1

PXD047492 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe effect of semaglutide on high-fat diet-induced liver cancer in obese mice
DescriptionThis study aims to investigate the impact of semaglutide on the expression of liver cancer proteins in obese mice induced by a high-fat diet. Sixteen obese mice were randomly divided into two groups: the high-fat diet group and the semaglutide group, each consisting of eight mice. Additionally, eight normal male mice were included as the control group. Serum samples were collected, and a differential expression analysis of total proteins in adipose tissue was performed using quantitative tandem mass spectrometry (TMT) in combination with liquid chromatography-tandem mass spectrometry (LC-MS/MS). Significant differential proteins were identified and subjected to bioinformatics analysis. The findings revealed that these differential proteins, namely ITGAV (integrin αV), LAMC1 (laminin γ1), FABP5 (fatty acid-binding protein 5), and LPL (lipoprotein lipase), regulate the occurrence and development of liver cancer by participating in the extracellular matrix (ECM) signaling pathway and the peroxisome proliferator-activated receptor (PPAR) signaling pathway. Notably, semaglutide can decelerate the progression of liver cancer by inducing the expression of ITGAV, LAMC1, FABP5, and LPL in the adipose tissue of obese mice.
HostingRepositoryiProX
AnnounceDate2023-12-04
AnnouncementXMLSubmission_2023-12-03_23:55:20.104.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYanhui Liu
SpeciesList scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-12-03 23:54:57ID requested
12023-12-03 23:55:20announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: LIHC, obesity, cancer, semaglutide, adipose tissue
Contact List
Shuchun Chen
contact affiliationHebei General Hospital
contact emailchenshuchunwork88@163.com
lab head
Yanhui Liu
contact affiliationHebei North University
contact emailliuyanhui0504@163.com
dataset submitter
Full Dataset Link List
iProX dataset URI