PXD046977 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | CoIP-MS based method to identify FNIP1 binding proteins in exercising muscle |
Description | Using muscle-specific FNIP1 (WT) and FNIP1 (S220A Tg) muscle tissues, we identified approximately 600 potential FNIP1 (WT) or FNIP1 (S220A) binding proteins in exercising muscle tissue of the corresponding mice by the CoIP-MS method, proteomic analysis showed that both FNIP1 (WT) and FNIP1 (S220A) interacted with major mitochondrial proteins, such as the respiratory complex subunits. Notably, FNIP1 (S220A) specifically interacted with additional mitochondrial subunits that were not observed for FNIP1 (WT), including protein involved in NADH metabolism and sulfur cluster binding. These data suggested that non-phosphorylated FNIP1 (S220A) could enhance its interaction with mitochondria. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-17 |
AnnouncementXML | Submission_2023-11-17_04:41:55.493.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Lei Fang |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | TripleTOF 5600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-11-14 19:37:36 | ID requested | |
⏵ 1 | 2023-11-17 04:41:55 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Mouse, CoIP., muscle |
Contact List
Lei Fang |
contact affiliation | Medical School of Nanjing University |
contact email | njfanglei@nju.edu.cn |
lab head | |
Lei Fang |
contact affiliation | Nanjing University Medical School |
contact email | njfanglei@nju.edu.cn |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD046977
- Label: PRIDE project
- Name: CoIP-MS based method to identify FNIP1 binding proteins in exercising muscle