PXD046977

PXD046977 is an original dataset announced via ProteomeXchange.

Title	CoIP-MS based method to identify FNIP1 binding proteins in exercising muscle
Description	Using muscle-specific FNIP1 (WT) and FNIP1 (S220A Tg) muscle tissues, we identified approximately 600 potential FNIP1 (WT) or FNIP1 (S220A) binding proteins in exercising muscle tissue of the corresponding mice by the CoIP-MS method, proteomic analysis showed that both FNIP1 (WT) and FNIP1 (S220A) interacted with major mitochondrial proteins, such as the respiratory complex subunits. Notably, FNIP1 (S220A) specifically interacted with additional mitochondrial subunits that were not observed for FNIP1 (WT), including protein involved in NADH metabolism and sulfur cluster binding. These data suggested that non-phosphorylated FNIP1 (S220A) could enhance its interaction with mitochondria.
HostingRepository	PRIDE
AnnounceDate	2023-11-17
AnnouncementXML	Submission_2023-11-17_04:41:55.493.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lei Fang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-14 19:37:36	ID requested
⏵ 1	2023-11-17 04:41:55	announced

Dataset with its publication pending

submitter keyword: Mouse, CoIP., muscle

Lei Fang
contact affiliation	Medical School of Nanjing University
contact email	njfanglei@nju.edu.cn
lab head
Lei Fang
contact affiliation	Nanjing University Medical School
contact email	njfanglei@nju.edu.cn
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD046977
     1. Label: PRIDE project
     2. Name: CoIP-MS based method to identify FNIP1 binding proteins in exercising muscle