PXD046916-1

PXD046916 is an original dataset announced via ProteomeXchange.

Title	Chemical proteomics reveals mechanisms of bacterial response to ROS mediated by antibiotics
Description	Increasing bacterial resistance has become a major threat to human health, and a more comprehensive and in-depth understanding of the mechanisms of antibiotic sterilization can help us better address the problem of bacterial resistance. A variety of antibiotics have been proposed to cause bacterial death, in part by increasing the steady-state levels of reactive oxygen species (ROS) in bacteria. However, it is unclear which proteins are modified by the ROS produced by these antibiotics and their role in antibiotic susceptibility/resistance. To answer this question, we firstly performed systematic identification of 8 antibiotics targets using our established chemoproteomics
HostingRepository	iProX
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-13_19:41:59.899.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ling Fu
SpeciesList	scientific name: Escherichia coli; NCBI TaxID: 562;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-13 19:41:31	ID requested
⏵ 1	2023-11-13 19:42:00	announced

Dataset with its publication pending

submitter keyword: Antibiotic resistance, Reactive oxygen species, Cys oxidation, redox proteomics

Jing Yang
contact affiliation	National Center for Protein Sciences (Beijing)
contact email	yangjing54@hotmail.com
lab head
Ling Fu
contact affiliation	National Center for Protein Sciences (Beijing)
contact email	flsmt@163.com
dataset submitter

iProX dataset URI