PXD046916
PXD046916 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Chemical proteomics reveals mechanisms of bacterial response to ROS mediated by antibiotics |
Description | Increasing bacterial resistance has become a major threat to human health, and a more comprehensive and in-depth understanding of the mechanisms of antibiotic sterilization can help us better address the problem of bacterial resistance. A variety of antibiotics have been proposed to cause bacterial death, in part by increasing the steady-state levels of reactive oxygen species (ROS) in bacteria. However, it is unclear which proteins are modified by the ROS produced by these antibiotics and their role in antibiotic susceptibility/resistance. To answer this question, we firstly performed systematic identification of 8 antibiotics targets using our established chemoproteomics |
HostingRepository | iProX |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-13_19:41:59.899.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Ling Fu |
SpeciesList | scientific name: Escherichia coli; NCBI TaxID: 562; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Q Exactive HF-X |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2023-11-13 19:41:31 | ID requested | |
⏵ 1 | 2023-11-13 19:42:00 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Antibiotic resistance, Reactive oxygen species, Cys oxidation, redox proteomics |
Contact List
Jing Yang | |
---|---|
contact affiliation | National Center for Protein Sciences (Beijing) |
contact email | yangjing54@hotmail.com |
lab head | |
Ling Fu | |
contact affiliation | National Center for Protein Sciences (Beijing) |
contact email | flsmt@163.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |