PXD046873 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Multiple plex quantitative proteomic analysis of neuroserpin-deficient and control mice, for the murine brain, retain and optic nerve |
Description | Neural regeneration and neuroprotection represent promising therapeutic approaches for neurodegenerative disorders like Alzheimer's disease (AD) or glaucoma. However, the molecular mechanisms that lead to neuroprotection are not clearly understood. One of the promising candidates to revive physiological function is neuroserpin (Serpini1), a serine protease inhibitor expressed by neurons which selectively inhibits extracellular tissue-type plasminogen activator (tPA)/plasmin and plays a neuroprotective role during ischemic brain injury. Abnormal function of this protein has been implicated in stroke, glaucoma, AD and FENIB. Here we report proteome changes by neuroserpin modulation in brains, retinas, and optic nerves from 12-month C57BL6/J neuroserpin deficient mice (NeuS-/-). |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-13 |
AnnouncementXML | Submission_2023-11-12_16:50:08.089.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | ShahabMirshahvaladi |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-11-12 06:29:50 | ID requested | |
⏵ 1 | 2023-11-12 16:50:08 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: neuroserpin, frontal cortex, brain, TMT proteomics, cerebellum, optic nerve, visual cortex, retina |
Contact List
VivekGupta |
contact affiliation | Macquarie Medical School, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia |
contact email | vivek.gupta@mq.edu.au |
lab head | |
ShahabMirshahvaladi |
contact affiliation | Macquarie University |
contact email | seyed-shahab-oddin.mirshahv@hdr.mq.edu.au |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD046873
- Label: PRIDE project
- Name: Multiple plex quantitative proteomic analysis of neuroserpin-deficient and control mice, for the murine brain, retain and optic nerve