PXD046873

PXD046873 is an original dataset announced via ProteomeXchange.

Title	Multiple plex quantitative proteomic analysis of neuroserpin-deficient and control mice, for the murine brain, retain and optic nerve
Description	Neural regeneration and neuroprotection represent promising therapeutic approaches for neurodegenerative disorders like Alzheimer's disease (AD) or glaucoma. However, the molecular mechanisms that lead to neuroprotection are not clearly understood. One of the promising candidates to revive physiological function is neuroserpin (Serpini1), a serine protease inhibitor expressed by neurons which selectively inhibits extracellular tissue-type plasminogen activator (tPA)/plasmin and plays a neuroprotective role during ischemic brain injury. Abnormal function of this protein has been implicated in stroke, glaucoma, AD and FENIB. Here we report proteome changes by neuroserpin modulation in brains, retinas, and optic nerves from 12-month C57BL6/J neuroserpin deficient mice (NeuS-/-).
HostingRepository	PRIDE
AnnounceDate	2023-11-13
AnnouncementXML	Submission_2023-11-12_16:50:08.089.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	ShahabMirshahvaladi
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-12 06:29:50	ID requested
⏵ 1	2023-11-12 16:50:08	announced

Dataset with its publication pending

submitter keyword: neuroserpin, frontal cortex, brain, TMT proteomics, cerebellum, optic nerve, visual cortex, retina

VivekGupta
contact affiliation	Macquarie Medical School, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia
contact email	vivek.gupta@mq.edu.au
lab head
ShahabMirshahvaladi
contact affiliation	Macquarie University
contact email	seyed-shahab-oddin.mirshahv@hdr.mq.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/11/PXD046873

PRIDE project URI

• PRIDE
  1. PXD046873
     1. Label: PRIDE project
     2. Name: Multiple plex quantitative proteomic analysis of neuroserpin-deficient and control mice, for the murine brain, retain and optic nerve