PXD045945-2
PXD045945 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | PD-L1 Mediated Immune Evasion in Triple Negative Breast Cancer Is Linked to the Loss of ZNF652 |
Description | The intrinsic regulation of PD-L1 expression remains unclear. Here we report that ZNF652 is a potent transcription repressor of PD-L1. ZNF652 frequently loses heterozygosity (LOH) in various cancers. Higher LOH rate and lack of estrogen-inducible transcription lead to suppressed expression of ZNF652 in triple-negative breast cancer (TNBC). Mechanistically, ZNF652 is physically associated with the NuRD transcription corepressor complex to repress a cohort of genes, including PD-L1. Overexpression of ZNF652 inhibits PD-L1 transcription, whereas depletion of ZNF652 upregulates PD-L1. Loss of ZNF652 in TNBC unleashes PD-L1-mediated immune evasion both in vitro and in vivo. Significantly, ZNF652 expression is progressively lost during breast cancer progression, and low ZNF652 level is correlated with elevated PD-L1 expression, less infiltrated CD8+ T cells, and poor prognosis in TNBC. Our study provides novel insights into PD-L1 regulation, and supports the pursuit of ZNF652 as a potential biomarker and drug target for breast cancer immunotherapy. |
HostingRepository | iProX |
AnnounceDate | 2023-09-29 |
AnnouncementXML | Submission_2023-12-18_20:04:22.357.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Haohao Tang |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2023-10-06 22:30:36 | ID requested | |
1 | 2023-10-06 22:30:50 | announced | |
⏵ 2 | 2023-12-18 20:04:23 | announced | 2023-12-19: Update information. |
Publication List
Liu Y, Peng Y, Du W, Yu C, Peng Z, Qin L, Ma Y, Wu X, Peng Y, Cheng X, Xia L, Fa H, Wu Y, Sun L, Liu J, Liu Z, Shang Y, Wang S, Liang J, PD-L1-mediated immune evasion in triple-negative breast cancer is linked to the loss of ZNF652. Cell Rep, 42(11):113343(2023) [pubmed] |
Keyword List
submitter keyword: Cancer immune evasion, PD-L1, breast cancer, transcription repression, ZNF652 |
Contact List
Yang Chen | |
---|---|
contact affiliation | Peking University Health Science Center |
contact email | chenyang1816185048@bjmu.edu.cn |
lab head | |
Haohao Tang | |
contact affiliation | Peking University Health Science Center |
contact email | Tanghaohao0987@163.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |