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PXD045715-1

PXD045715 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleChemoproteomics-guided development of SLC15A4 inhibitors with anti-inflammatory activity
DescriptionSLC15A4 is an endolysosome-resident transporter intimately linked with autoinflammation and autoimmunity. Specifically, SLC15A4 is critical for Toll-like receptor (TLR) 7-9 as well as the nucleotide-binding oligomerization domain-containing protein (NOD) signaling in several immune cell subsets. Notably, SLC15A4 is essential for the development of systemic lupus erythematosus in murine models and is associated with autoimmune conditions in humans. Despite its therapeutic potential, to our knowledge no chemical probes have been developed that target SLC15A4. Here, we use an integrated chemical proteomics approach to develop a suite of chemical tools, including first-in-class functional inhibitors, for SLC15A4. We demonstrate SLC15A4 inhibitors described herein suppress endolysosomal TLR and NOD functions in a variety of human and mouse immune cells, furnish evidence of their ability to suppress inflammation in vivo and in clinical settings, and provide insights into their mechanism of action. Our findings establish SLC15A4 as a druggable target for the treatment of autoimmune/autoinflammatory conditions.
HostingRepositoryPRIDE
AnnounceDate2023-11-30
AnnouncementXMLSubmission_2023-11-29_17:17:30.854.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterWeichao Li
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos; Orbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-09-26 16:38:16ID requested
12023-11-29 17:17:31announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Chemoproteomic, anti-inflammatory,SLC15A4
Contact List
Christopher Parker
contact affiliationScripps Research
contact emailcparker@scripps.edu
lab head
Weichao Li
contact affiliationThe Scripps Research Institute
contact emailwli@scripps.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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