PXD043471-1
PXD043471 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic Dynamics of Breast Cancer Cell Lines Identifies Potential Therapeutic Protein Targets |
Description | Treatment and relevant targets for breast cancer (BC) remain limited, especially for triple-negative BC (TNBC). We identified 6091 proteins of 76 human BC cell lines using data-independent acquisition (DIA). Integrating prior multi-omics datasets with our proteomic results, we found that including proteomics data improved drug sensitivity predictions and provided insights into mechanism of action. We then profiled the proteome changes in nine cell lines (five TNBC, four non-TNBC) treated with EGFR/AKT/mTOR inhibitors. In TNBC, metabolism pathways were dysregulated after EGFR/mTOR inhibitor treatment, while RNA modification and cell cycle pathways were affected by AKT inhibitor. This systematic multi-omics and in-depth analysis of the proteome of BC cells can help prioritize potential therapeutic targets and provides insights into adaptive resistance in TNBC. |
HostingRepository | iProX |
AnnounceDate | 2023-07-03 |
AnnouncementXML | Submission_2023-07-03_01:56:28.450.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Tiannan Guo |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue |
Instrument | TripleTOF 5600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2023-07-03 01:56:01 | ID requested | |
⏵ 1 | 2023-07-03 01:56:29 | announced |
Publication List
Sun R, Ge W, Zhu Y, Sayad A, Luna A, Lyu M, Liang S, Tobalina L, Rajapakse VN, Yu C, Zhang H, Fang J, Wu F, Xie H, Saez-Rodriguez J, Ying H, Reinhold WC, Sander C, Pommier Y, Neel BG, Aebersold R, Guo T, Proteomic Dynamics of Breast Cancer Cell Lines Identifies Potential Therapeutic Protein Targets. Mol Cell Proteomics, 22(8):100602(2023) [pubmed] |
Keyword List
submitter keyword: Triple-negative breast cancer, Data-independent acquisition, Proteomics, Proteotype |
Contact List
Yi Zhu | |
---|---|
contact affiliation | Westlake University |
contact email | zhuyi@westlake.edu.cn |
lab head | |
Tiannan Guo | |
contact affiliation | Westlake University |
contact email | guotiannan@westlake.edu.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |