<<< Full experiment listing

PXD042551-1

PXD042551 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleExtracellular matrix orchestration of tissue remodelling during chronic colitis
DescriptionUlcerative colitis is a debilitating and recurrent condition with significant co-morbidities including risk of developing cancer and that is associated with extensive tissue remodeling that is both a consequence and mediator of disease progression. Here, label-free mass spectrometry was used to characterise extracellular matrix remodelling in a murine model of colitis. Unique proteomic profiles of the extracellular matrix landscape distinguished inflamed from matched-normal colon tissue thus identifying pre- and pathological colitic states that were predominantly differentiated by expression of proteoglycans. Network maps derived from this dataset highlighted a central role for matrisomal proteins in epithelial-stromal interactions and identified orchestrating nodes that could be exploited in selection of therapeutic targets.
HostingRepositoryMassIVE
AnnounceDate2023-12-06
AnnouncementXMLSubmission_2023-12-06_18:59:38.359.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJoanna Bons
SpeciesList scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Eclipse
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-05-30 16:06:49ID requested
12023-12-06 18:59:38announced
Publication List
no publication
Keyword List
submitter keyword: Inflammatory Bowel Diseases, Extracellular Matrix, Proteoglycans, Quantitative Proteomics, Data-Independent Acquisition (DIA)
Contact List
Birgit Schilling
contact affiliationBuck Institute
contact emailbschilling@buckinstitute.org
lab head
Joanna Bons
contact affiliationBuck Institute for Research on Aging
contact emailjbons@buckinstitute.org
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000092056/