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PXD042262-1

PXD042262 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSystems level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation
DescriptionThere is a penury of regents and methods that enable the identification, analysis, and modulation of context-specific protein-protein interaction (PPI) network dysfunctions in native (unengineered) cells and tissues. Herein, we take advantage of first-in-class chemical binders of maladaptive scaffolding structures termed epichaperomes and develop an epichaperome-based ‘omics platform, epichaperomics, to identify PPI alterations in disease. We provide multiple lines of evidence, at both biochemical and functional levels, demonstrating the importance of these probes to identify and study PPI network dysfunctions and provide mechanistically and therapeutically relevant proteome-wide insights. As proof-of-principle, we derive systems level insight into PPI dysfunctions of cancer cells which enabled the discovery of a context-dependent mechanism by which cancer cells enhance the fitness of mitotic protein networks. Importantly, our systems levels analyses support the use of epichaperome chemical binders as therapeutic strategies aimed at normalizing PPI networks
HostingRepositoryMassIVE
AnnounceDate2023-05-16
AnnouncementXMLSubmission_2023-05-16_07:50:28.276.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterHediye Erdjument-Bromage
SpeciesList scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive; Q Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-05-16 07:48:35ID requested
12023-05-16 07:50:28announced
Publication List
no publication
Keyword List
submitter keyword: Epichaperome, protein-protein interactions, cancer proteomics
Contact List
Dr. Thomas A. Neubert
contact affiliationNew York University School of Medicine
contact emailThomas.Neubert@med.nyu.edu
lab head
Dr. Gabriela Chiosis
contact affiliationMemorial Sloan Kettering Cancer Center
contact emailchiosisg@mskcc.org
lab head
Hediye Erdjument-Bromage
contact affiliationNYU School of Medicine
contact emailhediye.bromage@med.nyu.edu
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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