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PXD041990-1

PXD041990 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCarnitine palmitoyltransferase 1A promotes mitochondrial fission by enhancing MFF succinylation in ovarian cancer
DescriptionMitochondria are dynamic organelles that are important for cell growth and proliferation. Dysregulated mitochondrial dynamics are highly associated with the initiation and progression of various cancers, including ovarian cancer. However, the regulatory mechanism underlying mitochondrial dynamics is still not fully understood. Previously, our study showed that carnitine palmitoyltransferase 1A (CPT1A) is highly expressed in ovarian cancer cells and promotes the development of ovarian cancer. Here, we find that CPT1A regulates mitochondrial dynamics and promotes mitochondrial fission in ovarian cancer cells. Our study futher shows that CPT1A regulates mitochondrial fission and function through mitochondrial fission factor (MFF) to promote the growth and proliferation of ovarian cancer cells. Mechanistically, we show that CPT1A promotes succinylation of MFF at lysine 302 (K302), which protects against Parkin-mediated ubiquitin-proteasomal degradation of MFF. Finally, the study shows that MFF is highly expressed in ovarian cancer cells and that high MFF expression is associated with poor prognosis in patients with ovarian cancer. MFF inhibition significantly inhibits the progression of ovarian cancer in vivo. Overall, CPT1A regulates mitochondrial dynamics through MFF succinylation to promote the development of ovarian cancer. Moreover, our findings suggest that MFF is a potential therapeutic target for ovarian cancer.
HostingRepositoryPRIDE
AnnounceDate2023-05-15
AnnouncementXMLSubmission_2023-05-14_19:57:03.294.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYaqinZhu
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListN6-succinyl-L-lysine
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-05-04 16:25:38ID requested
12023-05-14 19:57:03announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: mitochondrial dynamics
MFF
succinylation
ovarian cancer
Contact List
HuanjieShao
contact affiliationShaanxi Normal University
contact emailhshao@snnu.edu.cn
lab head
YaqinZhu
contact affiliationShaanxi Normal University
contact email15536387032@163.com
dataset submitter
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Dataset FTP location
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