PXD040561

PXD040561 is an original dataset announced via ProteomeXchange.

Title	Human HNF1A KI mice liver proteome analysis
Description	Nonalcoholic fatty liver disease (NAFLD) is a pathological condition caused by excessive fat accumulation in liver. HNF1A is the pathogenic cause of hepatocellular adenoma and HCC. It is an important transcription factor in liver. We constructed a knock-in mice expressing a human dominant negative HNF1α P291fsinsC mutation to explore how the pathogenic mutant affected lipid metabolism. Three liver samples of control group and four liver samples of KI group were used to do proteome analysis.
HostingRepository	iProX
AnnounceDate	2023-03-02
AnnouncementXML	Submission_2023-10-26_19:07:47.217.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Moke Liu
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-03-02 18:20:14	ID requested
1	2023-04-16 21:16:08	announced
2	2023-08-09 19:48:51	announced	2023-08-10: Update information.
⏵ 3	2023-10-26 19:07:48	announced	2023-08-10: Update information. 2023-10-27: Update publication information.

Liu M, Liu L, Guo H, Fan X, Liu T, Xu C, He Z, Song Y, Gao L, Shao S, Zhao J, Lu P, mutant promotes liver steatosis and inflammation by regulating hepatic complement factor D. iScience, 26(10):108018(2023) [pubmed]

submitter keyword: Human, liver, HNF1A

Jiajun Zhao
contact affiliation	Department of Endocrinology, Shandong Provincial Hospital
contact email	jjzhao@sdu.edu.cn
lab head
Moke Liu
contact affiliation	Shandong Provincial Hospital
contact email	81702352@qq.com
dataset submitter

iProX dataset URI