Update information. Update publication information. Nonalcoholic fatty liver disease (NAFLD) is a pathological condition caused by excessive fat accumulation in liver. HNF1A is the pathogenic cause of hepatocellular adenoma and HCC. It is an important transcription factor in liver. We constructed a knock-in mice expressing a human dominant negative HNF1α P291fsinsC mutation to explore how the pathogenic mutant affected lipid metabolism. Three liver samples of control group and four liver samples of KI group were used to do proteome analysis.