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PXD040128-1

PXD040128 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleA contractile injection system is required for developmentally regulated cell death in Streptomyces coelicolor
DescriptionDiverse bacterial species produce extracellular contractile injection systems (eCISs). Although closely related to contractile phage tails, eCISs can inject toxic proteins into eukaryotic cells. Thus, these systems are commonly viewed as cytotoxic defense mechanisms that are not central to other aspects of bacterial biology. Here, we provide evidence that eCISs appear to participate in the complex developmental process of the bacterium Streptomyces coelicolor. In particular, we show that S. coelicolor produces eCIS particles during its normal growth cycle, and that strains lacking functional eCIS particles exhibit pronounced alterations in their developmental program.
HostingRepositoryMassIVE
AnnounceDate2023-02-20
AnnouncementXMLSubmission_2023-02-20_15:20:48.423.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMaria Vladimirov
SpeciesList scientific name: Streptomyces coelicolor A3(2); NCBI TaxID: 100226;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-02-15 14:03:26ID requested
12023-02-20 15:20:48announced
Publication List
no publication
Keyword List
submitter keyword: Streptomyces, phage tail, contractile injection system
Contact List
Alan Davidson
contact affiliationUniversity
contact emailalan.davidson@utoronto.ca
lab head
Maria Vladimirov
contact affiliationUniversity of Toronto
contact emailmariavld118@gmail.com
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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