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PXD038966-1

PXD038966 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomics analysis on SETD2 loss induced ccRCC formation
DescriptionPatients with polycystic kidney disease (PKD) encounter a high risk of clear cell renal cell carcinoma (ccRCC), a malignant tumor with dysregulated lipid metabolism. SET domain–containing 2 (SETD2) has been identified as an important tumor suppressor gene in ccRCC. However, the role of SETD2 in tumorigenesis during the transition from PKD to ccRCC remains largely unexplored. Herein, we performed metabolomics, lipidomics, transcriptomics and proteomics with SETD2 loss induced PKD-ccRCC transition mouse model. To characterize biological responses triggered by SETD2 deletion during PKD-ccRCC transition at the protein level, we conducted global proteomics studies.
HostingRepositoryPRIDE
AnnounceDate2023-10-31
AnnouncementXMLSubmission_2023-10-31_05:47:14.709.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterRaohanyu
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentLTQ Orbitrap
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-12-20 06:55:30ID requested
12023-10-31 05:47:15announced
Publication List
Dataset with its publication pending
Keyword List
ProteomeXchange project tag: Cancer (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project
submitter keyword: Polycystic kidney disease (PKD), SET domain–containing 2 (SETD2), Clear cell renal cell carcinoma (ccRCC)
Contact List
XiantingDing
contact affiliationShanghai Jiao Tong University
contact emaildingxianting@sjtu.edu.cn
lab head
Raohanyu
contact affiliationShanghai Jiao Tong University
contact emailraohanyu@sjtu.edu.cn
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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