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PXD038557-2

PXD038557 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleBrain heterotopia formation by ciliopathic breakdown of neuroepithelial and blood-cerebrospinal fluid barriers
DescriptionIn this study, we found that ablation of genes encoding ciliary transport proteins such as intraflagellar transport homolog 88 (Ift88) and kinesin family member 3a (Kif3a) in cortical radial progenitors led to periventricular heterotopia during late mouse embryogenesis. Conditional mutation of primary cilia unexpectedly caused breakdown of both the neuroepithelial lining and the blood-choroid plexus barrier. Choroidal leakage was partially caused by enlargement of the choroid plexus in the cilia mutants. We found that the choroid plexus expressed platelet-derived growth factor A (Pdgf-A) and that Pdgf-A expression was ectopically increased in cilia-mutant embryos. Cortices obtained from embryos in utero electroporated with Pdgfa mimicked periventricular heterotopic nodules of the cilia mutant.
HostingRepositoryPRIDE
AnnounceDate2023-01-13
AnnouncementXMLSubmission_2023-01-13_15:15:34.455.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJaemyungJang
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-12-05 06:26:03ID requested
12023-01-09 17:39:20announced
22023-01-13 15:15:34announced2023-01-13: Updated project metadata.
32023-11-14 08:58:36announced2023-11-14: Updated project metadata.
Publication List
Keyword List
submitter keyword: cerebrospinal fluid,LC-MSMS
Contact List
YoungshikChoe1
contact affiliation1Korea Brain Research Institute
contact emaildallarae@kbri.re.kr
lab head
JaemyungJang
contact affiliationKorea Brain Research Institute
contact emailpiloter2@kbri.re.kr
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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