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PXD038407-2

PXD038407 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleImproving SWATH-MS analysis by Deep-learning
DescriptionTo be able to reliably generate theoretical libraries that can be used in SWATH experiments, we developed a prediction framework, deep-learning for SWATH analysis (dpSWATH), to improve the sensitivity and specificity of data generated by Q-TOF mass spectrometers. The theoretical library built by dpSWATH allowed us to increase the identification rate of proteins and peptides compared to traditional or library-free methods. Especially, the in-silico library built based on the transcriptome scale identified the most proteins while kept a similar FDR as DDA library. Based on our analysis we conclude that dpSWATH is superior in predicting libraries that can be used for SWATH-MS measurements compared to other algorithms that are based on Orbitrap data.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:58:31.339.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterBo Sun
SpeciesList scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: 7227;
ModificationListNo PTMs are included in the dataset
InstrumentTripleTOF 6600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-11-26 05:11:55ID requested
12023-01-16 03:51:46announced
22023-11-14 08:58:31announced2023-11-14: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: TripleTOF 6600, Embryo, D.melanogaster
Contact List
Prof. Dr. Axel Imhof
contact affiliationHistone Modifications Group Zentrallabor für Proteinanalytik BioMedical Center Faculty of Medicine Ludwig-Maximilians-University of Munich
contact emailimhof@lmu.de
lab head
Bo Sun
contact affiliationLMU
contact emaildpSWATH.sun@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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