PXD038261-1
PXD038261 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | OTU7B modulates the mosquito immune response to Beauveria bassiana infection via deubiquitination of the Toll adaptor TRAF4 |
Description | Insects use innate immunity to defend microbial infection. Toll pathway is a major immune signaling pathway that is associated with antifungal immune response in mosquitoes. Our study identified a fungal-induced deubiquitinase, OTU7B, which, when knocked out, promotes the translocation of the NF-κB factor Rel1 into the nucleus and confers enhanced resistance to fungal infection. We further found the counterpart of OTU7B, TRAF4, which is a component of Toll pathway and acts as an adaptor protein. |
HostingRepository | iProX |
AnnounceDate | 2022-11-22 |
AnnouncementXML | Submission_2022-11-22_00:37:31.340.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yanhong Wang |
SpeciesList | scientific name: Aedes aegypti; NCBI TaxID: 7159; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2022-11-22 00:37:09 | ID requested | |
⏵ 1 | 2022-11-22 00:37:31 | announced | |
2 | 2023-02-20 19:03:56 | announced | 2023-02-21: Update information. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: innate immunity |
Contact List
Zhen Zou | |
---|---|
contact affiliation | Institute of Zoology, Chinese Academy of Sciences |
contact email | zouzhen@ioz.ac.cn |
lab head | |
Yanhong Wang | |
contact affiliation | Institute of Zoology, Chinese Academy of Sciences |
contact email | wangyanhong@ioz.ac.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |