PXD038261

PXD038261 is an original dataset announced via ProteomeXchange.

Title	OTU7B modulates the mosquito immune response to Beauveria bassiana infection via deubiquitination of the Toll adaptor TRAF4
Description	Insects use innate immunity to defend microbial infection. Toll pathway is a major immune signaling pathway that is associated with antifungal immune response in mosquitoes. Our study identified a fungal-induced deubiquitinase, OTU7B, which, when knocked out, promotes the translocation of the NF-κB factor Rel1 into the nucleus and confers enhanced resistance to fungal infection. We further found the counterpart of OTU7B, TRAF4, which is a component of Toll pathway and acts as an adaptor protein.
HostingRepository	iProX
AnnounceDate	2022-11-22
AnnouncementXML	Submission_2023-02-20_19:03:55.430.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yanhong Wang
SpeciesList	scientific name: Aedes aegypti; NCBI TaxID: 7159;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-11-22 00:37:09	ID requested
1	2022-11-22 00:37:31	announced
⏵ 2	2023-02-20 19:03:56	announced	2023-02-21: Update information.

Wang Y, Chang M, Wang M, Ji Y, Sun X, Raikhel AS, Zou Z, OTU7B Modulates the Mosquito Immune Response to Beauveria bassiana Infection via Deubiquitination of the Toll Adaptor TRAF4. Microbiol Spectr, 11(1):e0312322(2023) [pubmed]

submitter keyword: innate immunity

Zhen Zou
contact affiliation	Institute of Zoology, Chinese Academy of Sciences
contact email	zouzhen@ioz.ac.cn
lab head
Yanhong Wang
contact affiliation	Institute of Zoology, Chinese Academy of Sciences
contact email	wangyanhong@ioz.ac.cn
dataset submitter

iProX dataset URI