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PXD038238-2

PXD038238 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleBacteria Commonly Associated with Central Nervous System Catheter Infections Elicit Distinct CSF Proteome Signatures
DescriptionCerebrospinal fluid (CSF) shunt infection is a common and devastating complication of the treatment of hydrocephalus. Timely and accurate diagnosis is essential as these infections can lead to long term neurologic consequences like seizures, decreased IQ and impaired school performance. Currently the diagnosis of shunt infection relies on bacterial culture, however, culture is not always accurate especially as these infections are frequently caused by bacteria capable of forming biofilms like Staphylococcus epidermidis, Cutibacterium acnes, and Pseudomonas aeruginosa and may have very few planktonic bacteria in the CSF to be picked up on culture. Therefore, there is a critical need to identify a new rapid, and accurate method for diagnosis of CSF shunt infection with broad bacterial species coverage to improve the long-term outcomes of children suffering from these infections.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:59:50.901.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterIshwor Thapa
SpeciesList scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-11-21 16:14:22ID requested
12023-01-30 10:33:04announced
22023-11-14 08:59:51announced2023-11-14: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: inflammation, P. aeruginosa, central nervous system infection, CNS, CSF, infection,Shunt infection, proteome, S. epidermidis, biomarker, C. acnes
Contact List
Dr. Gwenn L. Skar
contact affiliationDepartment of Pediatrics University of Nebraska Medical Center, Omaha, NE
contact emailgskar@unmc.edu
lab head
Ishwor Thapa
contact affiliationUniversity of Nebraska at Omaha
contact emailithapa@unomaha.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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