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PXD038226-1

PXD038226 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTEAD is required for DNA repair independent of its transcriptional function
DescriptionThe TEA domain family members 1-4 (TEADs) are major transcription factors for YAP/TAZ transcription activators in the Hippo pathway, regulating many biological processes, including development, tissue homeostasis, and tumorigenesis through target genes. Their amplification/upregulation correlates with poor prognosis in cancer patients. Although the Hippo pathway continues to be elucidated, it is clear that TEAD largely exerts its actions via transcriptional regulation. Here, we uncover an unexpected role for TEADs in the DNA damage response. Using comparative mass spectrometry, we demonstrate that TEADs interact with several DNA repair proteins. We further show that TEADs form DNA damage-induced nuclear foci that co-localize with DNA damage markers. We also found that TEADs are required for resistance to DNA damage, maintaining genome stability, and resolution of double strand break repair that is independent from the Hippo pathway and its transcriptional role. Our results establish a new role for TEADs in DNA repair and therefore, highlight a critical consideration in therapeutically targeting the Hippo pathway.
HostingRepositoryMassIVE
AnnounceDate2023-01-04
AnnouncementXMLSubmission_2023-01-04_07:37:44.032.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMeena Choi
SpeciesList scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue; phosphorylated residue
InstrumentLTQ Orbitrap Elite
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-11-21 15:05:54ID requested
12023-01-04 07:37:44announced
Publication List
no publication
Keyword List
submitter keyword: TEAD, GeLS-MS, Spectrum counting
Contact List
Jennie Lill
contact affiliationGenentech Inc
contact emailjlill@gene.com
lab head
Meena Choi
contact affiliationGenentech
contact emailchoimeena.ijae@gmail.com
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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