PXD038226
PXD038226 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | TEAD is required for DNA repair independent of its transcriptional function |
| Description | The TEA domain family members 1-4 (TEADs) are major transcription factors for YAP/TAZ transcription activators in the Hippo pathway, regulating many biological processes, including development, tissue homeostasis, and tumorigenesis through target genes. Their amplification/upregulation correlates with poor prognosis in cancer patients. Although the Hippo pathway continues to be elucidated, it is clear that TEAD largely exerts its actions via transcriptional regulation. Here, we uncover an unexpected role for TEADs in the DNA damage response. Using comparative mass spectrometry, we demonstrate that TEADs interact with several DNA repair proteins. We further show that TEADs form DNA damage-induced nuclear foci that co-localize with DNA damage markers. We also found that TEADs are required for resistance to DNA damage, maintaining genome stability, and resolution of double strand break repair that is independent from the Hippo pathway and its transcriptional role. Our results establish a new role for TEADs in DNA repair and therefore, highlight a critical consideration in therapeutically targeting the Hippo pathway. |
| HostingRepository | MassIVE |
| AnnounceDate | 2023-01-04 |
| AnnouncementXML | Submission_2023-01-04_07:37:44.032.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Meena Choi |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue; phosphorylated residue |
| Instrument | LTQ Orbitrap Elite |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-11-21 15:05:54 | ID requested | |
| ⏵ 1 | 2023-01-04 07:37:44 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: TEAD, GeLS-MS, Spectrum counting |
Contact List
| Jennie Lill | |
|---|---|
| contact affiliation | Genentech Inc |
| contact email | jlill@gene.com |
| lab head | |
| Meena Choi | |
| contact affiliation | Genentech |
| contact email | choimeena.ijae@gmail.com |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000090760/ |
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