PXD038114 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Mass spectrometry imaging of ancient teeth proteomes |
Description | In order to research the variation in protein distribution in teeth, proteins were extracted from archaeological (15-18th century, Netherlands) and modern teeth and identified using LC-MS/MS. Of the recovered proteins we then visualised the distribution of collagen type I (both the alpha-1 and -2 chains), alpha-2-HS-glycoprotein, haemoglobin subunit alpha and myosin light polypeptide 6 using MALDI-MSI. We found distinct differences in the spatial distributions of different proteins as well as between some peptides of the same protein. The reason for these differences in protein spatial distribution remain unclear, yet this study highlights the ability of MALDI-MSI for visualisng the spatial distribution of proteins in archaeological biomineralised tissues. Therefore MALDI-MSI might prove a useful tool to improve our understanding of protein preservation as well as aid in deciding sampling strategies. |
HostingRepository | PRIDE |
AnnounceDate | 2023-03-11 |
AnnouncementXML | Submission_2023-03-11_11:07:40.002.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD038114 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | JanDekker |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos; SYNAPT G2-Si |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-11-11 09:30:01 | ID requested | |
⏵ 1 | 2023-03-11 11:07:40 | announced | |
2 | 2023-11-14 08:43:50 | announced | 2023-11-14: Updated project metadata. |
Publication List
Dekker J, Larson T, Tzvetkov J, Harvey VL, Dowle A, Hagan R, Genever P, Schrader S, Soressi M, Hendy J, Spatial analysis of the ancient proteome of archeological teeth using mass spectrometry imaging. Rapid Commun Mass Spectrom, 37(8):e9486(2023) [pubmed] |
10.6019/PXD038114; |
Keyword List
submitter keyword: palaeoproteomics, teeth, protein distribution,MALDI-MSI, diagenesis |
Contact List
JessicaHendy |
contact affiliation | BioArCh, Department of Archaeology, University of York |
contact email | jessica.hendy@york.ac.uk |
lab head | |
JanDekker |
contact affiliation | University of York |
contact email | jan@palaeome.org |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD038114
- Label: PRIDE project
- Name: Mass spectrometry imaging of ancient teeth proteomes