PXD037920-2

PXD037920 is an original dataset announced via ProteomeXchange.

Title	Proteomics of Mouse Tumor ECM LC-MS/MS
Description	Type I, II, III and V collagens were commonly identified in human, pig, and mouse breast ECM. Mammary epithelial cells were able to form acini on certain types or combinations of the four collagens at normal breast tissue stiffness levels. Comparison of the collagen species in mouse normal breast and breast tumor ECM revealed common and distinct sets of collagens within the two types of tissues. Elevated collagen type I alpha 1 chain expression was found in human breast cancers. Collagen type XXV alpha 1 chain was identified in mouse breast tumors but not in normal breast tissues. Our data provide insights into modeling human breast pathophysiological structures and functions using native tissue-derived hydrogels and potential contributions of different collagen types or their monomers in breast cancer development.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_07:43:33.217.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD037920
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Weimin Li
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Agilent instrument model

Revision	Datetime	Status	ChangeLog Entry
0	2022-11-03 04:51:10	ID requested
1	2023-03-11 03:12:42	announced
⏵ 2	2023-11-14 07:43:34	announced	2023-11-14: Updated project metadata.

10.6019/PXD037920;

Keller CR, Ruud KF, Martinez SR, Li W, Identification of the Collagen Types Essential for Mammalian Breast Acinar Structures. Gels, 8(12):(2022) [pubmed]

submitter keyword: Mouse Tumor, Extracellular Matrix, LC-MS/MS

Weimin Li
contact affiliation	Washington State University
contact email	weimin.li@wsu.edu
lab head
Weimin Li
contact affiliation	Washington State University Spokane
contact email	weimin.li@wsu.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD037920

PRIDE project URI

• PRIDE
  1. PXD037920
     1. Label: PRIDE project
     2. Name: Proteomics of Mouse Tumor ECM LC-MS/MS