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PXD037918-2

PXD037918 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCitrullinated glucose-regulated protein 78 is a candidate target for cancer immunotherapy
DescriptionIn this study we investigate the potential of targeting citrullinated GRP78 for cancer therapy. We select five peptides and show the identification CD4 T cell responses to one citrullinated GRP78 epitope that is restricted through HLA DP*0401 and HLA-DR*0101 alleles. This peptide is detected by mass spectrometry in B16 melanoma grown in vivo and citrulline specific CD4 responses to this epitope mediate efficient therapy of established B16 melanoma tumours in HHDII/DP4 transgenic mouse model. We demonstrate the existence of a repertoire of responses to the citrullinated GRP78 peptide in healthy individuals.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:58:30.754.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMichael Bremang
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListL-citrulline
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-11-03 04:48:25ID requested
12022-11-29 06:07:08announced
22023-11-14 08:58:31announced2023-11-14: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Citrullination, peptidomics, immunotherapy, GRP78
Contact List
Victoria Brentville
contact affiliationScancell Unit 202 Bellhouse Building Sanders Road Oxford Science Park Oxford OX4 4GD UK
contact emailVictoriaBrentville@scancell.co.uk
lab head
Michael Bremang
contact affiliationProteome Sciences
contact emailmichael.bremang@proteomics.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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