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PXD037901-2

PXD037901 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleGABA regulates IL-1β production in macrophages
DescriptionNeurotransmitters have been well-documented to determine immune cell fates; however, whether and how γ-amino butyric acid (GABA) shapes the function of innate immune cells is still obscure. Here, we demonstrated that GABA orchestrates macrophage maturation and inflammation. GABA treatment during macrophage maturation inhibits interleukin (IL)-1β production from inflammatory macrophages. Mechanistically, GABA enhances succinate-FAD-lysine demethylase1 (LSD1) signaling to regulate the histone demethylation of Bcl2l11 and Dusp2, lowering the formation of NLRP3-ASC-Caspase-1 complex. Meanwhile, GABA-succinate axis lowers succinylation of mitochondrial proteins to promote mitochondrial oxidative phosphorylation (OXPHOS). We also found that GABA alleviates the LPS-induced sepsis as well as high-fat diet-induced obesity in mice. Our study proves that GABA is potential in lessening the pro-inflammatory macrophage responses associating with metabolic reprogramming and protein succinylation, thus providing a strategy for treating macrophage-related inflammatory diseases.
HostingRepositoryPRIDE
AnnounceDate2023-01-06
AnnouncementXMLSubmission_2023-01-06_08:32:30.780.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJianFu
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListsuccinylated residue
Instrumentautoflex
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-11-03 04:11:59ID requested
12022-11-29 09:06:50announced
22023-01-06 08:32:31announced2023-01-06: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Macrophage, Succinate, Succinylation,FAD, GABA
Contact List
JianFu
contact affiliationSouth China Agricultural University
contact emailarrow_f1997@qq.com
lab head
JianFu
contact affiliationSouth China Agricultural University
contact emailarrow_f1997@qq.com
dataset submitter
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Dataset FTP location
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