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PXD037892-2

PXD037892 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe Fgf/Erf/NCoR1/2 repressive axis controls trophoblast cell fate
DescriptionHere, we demonstrate that upon inhibition of the Fgf/Erk pathway in mouse trophoblast stem cells (TSCs), the Ets2 repressor factor (Erf) interacts with components of the Nuclear Receptor Corepressor Complex 1 and 2 (NCoR1 and NCoR2). Upon attenuation of Fgf signalling, unphosphorylated, nuclear Erf recruits the NCoR1/2 complex to key trophoblast genes, brings about their transcriptional silencing and facilitates differentiation and placental development.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_09:00:21.305.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterRichard Imre
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListmethylthiolated residue; phosphorylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF; Orbitrap Fusion Lumos; Q Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-11-03 04:03:37ID requested
12023-04-26 01:02:39announced
22023-11-14 09:00:21announced2023-11-14: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: trophoblast stem cells,Erf, NCoR2, NCoR1
Contact List
Paulina A. Latos
contact affiliationCenter for Anatomy and Cell Biology, Medical University of Vienna, Schwarzspanierstrasse 17, A-1090 Vienna, Austria Tel.: +4314016037718
contact emailpaulina.latos@meduniwien.ac.at
lab head
Richard Imre
contact affiliationIMBA Vienna
contact emailrichard.imre@imba.oeaw.ac.at
dataset submitter
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