PXD037555 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Endothelin-1, over-expressed in SOD1G93A mice, aggravates injury of NSC34-hSOD1G93A cells through complicated molecular mechanism revealed by quantitative proteomics analysis |
Description | Using proteomic analysis, we revealed that 110 proteins were differentially expressed in NSC34-hSOD1G93A cells after ET-1 treatment in our experiments, of which 54 were up-regulated and 56 were down-regulated. Bioinformatics analysis showed that the differentially expressed proteins (DEPs) were primarily enriched in hippo signaling pathway-multiple species, ABC transporters, ErbB signaling pathway and so on. These results provide further insights on the potential roles of ET-1 in ALS. Our study presents a new promising therapeutic target to protect MNs of ALS. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:43:16.399.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yingzhen Zhang |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-10-19 02:49:45 | ID requested | |
1 | 2023-03-11 10:17:59 | announced | |
⏵ 2 | 2023-11-14 08:43:24 | announced | 2023-11-14: Updated project metadata. |
Publication List
Zhang Y, Chen L, Li Z, Li D, Wu Y, Guo Y, mice, aggravates injury of NSC34-hSOD1G93A cells through complicated molecular mechanism revealed by quantitative proteomics analysis. Front Cell Neurosci, 16():1069617(2022) [pubmed] |
Keyword List
submitter keyword: LC-MS/MS Analysis |
Contact List
Guo Yansu |
contact affiliation | The second hospital of Hebei Medical University |
contact email | gys188@163.com |
lab head | |
Yingzhen Zhang |
contact affiliation | The second hospital of Hebei Medical University |
contact email | 2392669033@qq.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD037555 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD037555
- Label: PRIDE project
- Name: Endothelin-1, over-expressed in SOD1G93A mice, aggravates injury of NSC34-hSOD1G93A cells through complicated molecular mechanism revealed by quantitative proteomics analysis