PXD037555

PXD037555 is an original dataset announced via ProteomeXchange.

Title	Endothelin-1, over-expressed in SOD1G93A mice, aggravates injury of NSC34-hSOD1G93A cells through complicated molecular mechanism revealed by quantitative proteomics analysis
Description	Using proteomic analysis, we revealed that 110 proteins were differentially expressed in NSC34-hSOD1G93A cells after ET-1 treatment in our experiments, of which 54 were up-regulated and 56 were down-regulated. Bioinformatics analysis showed that the differentially expressed proteins (DEPs) were primarily enriched in hippo signaling pathway-multiple species, ABC transporters, ErbB signaling pathway and so on. These results provide further insights on the potential roles of ET-1 in ALS. Our study presents a new promising therapeutic target to protect MNs of ALS.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:43:16.399.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yingzhen Zhang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-19 02:49:45	ID requested
1	2023-03-11 10:17:59	announced
⏵ 2	2023-11-14 08:43:24	announced	2023-11-14: Updated project metadata.

Zhang Y, Chen L, Li Z, Li D, Wu Y, Guo Y, mice, aggravates injury of NSC34-hSOD1G93A cells through complicated molecular mechanism revealed by quantitative proteomics analysis. Front Cell Neurosci, 16():1069617(2022) [pubmed]

submitter keyword: LC-MS/MS Analysis

Guo Yansu
contact affiliation	The second hospital of Hebei Medical University
contact email	gys188@163.com
lab head
Yingzhen Zhang
contact affiliation	The second hospital of Hebei Medical University
contact email	2392669033@qq.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD037555

PRIDE project URI

• PRIDE
  1. PXD037555
     1. Label: PRIDE project
     2. Name: Endothelin-1, over-expressed in SOD1G93A mice, aggravates injury of NSC34-hSOD1G93A cells through complicated molecular mechanism revealed by quantitative proteomics analysis