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PXD037514-1

PXD037514 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleComprehensive and quantitative analysis of the changes in proteomic and phosphoproteomic profiles during stimulation and repression of steroidogenesis in MA-10 Leydig cells.
Description In the present study, we have used a quantitative LC-MS/MS approach using total and phosphopeptide-enriched proteins to identify the changes that occur in the proteome and phosphoproteome of MA-10 Leydig cells during both the stimulatory phase (Fsk/cAMP treatment) and inhibitory phase (AICAR-mediated activation of AMPK) of steroidogenesis. The phosphorylation level of several proteins, including some never before described in Leydig cells, was significantly altered during stimulation and inhibition of steroidogenesis. Our data provide new key insights into the finely tuned and dynamic processes that ensure adequate steroid hormone production.
HostingRepositoryMassIVE
AnnounceDate2022-10-25
AnnouncementXMLSubmission_2022-10-25_04:56:28.869.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJacques J. Tremblay
SpeciesList scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationListPhospho
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-10-17 07:53:42ID requested
12022-10-25 04:56:29announced
Publication List
no publication
Keyword List
submitter keyword: Testis, Leydig cells, Steroidogenesis, Star, AMPK, Phosphoproteomics, Proteomics
Contact List
Jacques J. Trembay
contact affiliationCHU de Quebec Universite Laval
contact emailjacques-j.tremblay@crchudequebec.ulaval.ca
lab head
Jacques J. Tremblay
contact affiliationUniversite Laval
contact emailJacques-J.Tremblay@crchudequebec.ulaval.ca
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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