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PXD037201-1

PXD037201 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIKACH IS CONSTITUTIVELY ACTIVE VIA PKC EPSILON IN AGING MEDIATED ATRIAL FIBRILLATION
DescriptionAtrial fibrillation (AF), the most common abnormal heart rhythm, is a major cause for stroke. Aging is the greatest risk factor for AF, however, specific ionic pathways that can elucidate how aging leads to AF remain elusive. We used young and old wild type (WT) and PKC epsilon (PKCepsilon) knockout (KO) mice, whole animal, and cellular electrophysiology, as well as whole heart, and cellular imaging to investigate how aging leads to the aberrant functioning of a potassium current, and consequently to AF facilitation. Our experiments showed that knocking out PKC epsilon abrogates the effects of aging on AF by preventing the development of a constitutively active acetylcholine sensitive inward rectifier potassium current (IKACh). Moreover, blocking this abnormal current in the old heart prevents AF inducibility. Our studies demonstrate that in the aging heart, IKACh is constitutively active in a PKC epsilon dependent manner, contributing to the perpetuation of AF
HostingRepositoryMassIVE
AnnounceDate2022-11-01
AnnouncementXMLSubmission_2022-11-01_08:37:33.034.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterElizabeth Wood
SpeciesList scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-10-07 08:26:45ID requested
12022-11-01 08:37:33announced
Publication List
no publication
Keyword List
submitter keyword: Aging, Atrial fibrillation, IKACh, PKC epsilon
Contact List
Sami Noujaim
contact affiliationUniversity of South Florida
contact emailsnoujaim@usf.edu
lab head
Elizabeth Wood
contact affiliationUSF
contact emailerwood@usf.edu
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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