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PXD037150-1

PXD037150 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleInterplay between acetylation and ubiquitination of Isw1 confers multidrug resistance in Cryptococcus neoformans
DescriptionLysine acetylation and ubiquitination are one of many protein modifications and play a crucial role in the biological regulation of many organisms, but little is known about the relationship between acetylation and ubiquitination few. Here, the Isw1 protein is an important member of the chromatin remodeling complex, and we performed single-protein modification mass spectrometry detection of the C. neoformans Isw1 protein and site mutations for both detected modifications. The data showed that the two modifications of Cryptococcus neoformans Isw1 protein have a balance of each other. Acetylation can maintain protein stability and maintain protein function, while ubiquitination can reduce protein level and maintain Isw1 protein expression. The expression level of Isw1 protein leads to resistance to antifungal drugs. These results reveal the resistance mechanism of Isw1 protein of Cryptococcus neoformans to antifungal drugs.
HostingRepositoryPRIDE
AnnounceDate2022-12-26
AnnouncementXMLSubmission_2022-12-26_06:19:39.803.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmittermengyang
SpeciesList scientific name: Candida albicans (Yeast); NCBI TaxID: 5476;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-10-03 11:19:11ID requested
12022-12-26 06:19:40announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: acetylation
ubiquitination
multidrug resistance
Contact List
YangMeng
contact affiliationCollege of Life and Health Sciences, Northeastern University, Shenyang, China.
contact emailMMMyang0130@163.com
lab head
mengyang
contact affiliation13940381361
contact emailMMMyang0130@163.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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