PXD037133-2

PXD037133 is an original dataset announced via ProteomeXchange.

Title	Integrated proteomics and network analysis identifies protein hubs and network alterations in Alzheimer’s disease
Description	We performed a systems-level study of disease-associated proteome changes in human frontal cortex of Alzheimer’s disease (AD) patients using an integrated approach that combines mass spectrometry-based quantitative proteomics, differential expression analysis, and co-expression network analysis. Our analyses of 16 human brain tissues from AD patients and age-matched controls showed organization of the cortical proteome into a network of 24 biologically meaningful modules of co-expressed proteins. Of these, 5 modules are positively correlated to AD phenotypes with hub proteins that are up-regulated in AD, and 6 modules are negatively correlated to AD phenotypes with hub proteins that are down-regulated in AD.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_07:54:41.985.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	QI ZHANG
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-02 03:57:39	ID requested
1	2022-10-04 19:58:33	announced
⏵ 2	2023-11-14 07:54:42	announced	2023-11-14: Updated project metadata.

Zhang Q, Ma C, Gearing M, Wang PG, Chin LS, Li L, Integrated proteomics and network analysis identifies protein hubs and network alterations in Alzheimer's disease. Acta Neuropathol Commun, 6(1):19(2018) [pubmed]

submitter keyword: proteomics, FASP,Alzheimer's disease

Lian Li
contact affiliation	Department of Pharmacology and Chemical Biology Emory University
contact email	lli5@emory.edu
lab head
QI ZHANG
contact affiliation	Emory University
contact email	QZHAN50@emory.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD037133

PRIDE project URI

• PRIDE
  1. PXD037133
     1. Label: PRIDE project
     2. Name: Integrated proteomics and network analysis identifies protein hubs and network alterations in Alzheimer’s disease