PXD037069

PXD037069 is an original dataset announced via ProteomeXchange.

Title	Quantitative proteomic analysis reveals the expression of various proteins in mice during the tumor treatment
Description	Based on the gene ontology (GO) results, we found that proteins associated with responses or processes related to stimulus, immune system, signalling, cell killing, and antioxidant activity were more up-regulated after MiBaMc treatment. In contrast, proteins that related to cell integrity and cell growth were more down-regulated. Those results indicated that MiBaMc induced strengthened tumour damage, which should be attributed to the synergistic effect induced by hyperthermia and ROS. Furthermore, the prominent upregulation of proteins associated with antioxidant activity also directly indicated the enhanced oxidative pressure of tumours in the MiBaMc treated group. Specifically, there were obvious overlays between proteins associated with heat shock, oxidative stress, and cell death. Thus both photothermal-induced hyperthermia and photodynamic-induced oxidative damage contributed to immune cell death. Moreover, a significant enhancement in the protein level associated with immune response was observed from the GO analysis, suggesting the antitumour capacity should be attributed to the systemic immune activation of the MiBaMc. This phenomenon can also be verified from the prominent overlays between proteins associated with immune response, inflammation, and bacteria infection.
HostingRepository	iProX
AnnounceDate	2022-09-28
AnnouncementXML	Submission_2023-05-29_19:59:47.362.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiawei Liu
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-09-28 19:27:24	ID requested
1	2022-09-28 19:27:50	announced
⏵ 2	2023-05-29 19:59:48	announced	2023-05-30: Update publication information.

Wang D, Liu J, Wang C, Zhang W, Yang G, Chen Y, Zhang X, Wu Y, Gu L, Chen H, Yuan W, Chen X, Liu G, Gao B, Chen Q, Zhao Y, Microbial synthesis of Prussian blue for potentiating checkpoint blockade immunotherapy. Nat Commun, 14(1):2943(2023) [pubmed]

submitter keyword: stimulus, immune system, signalling, cell killing, and antioxidant activity

Yanli Zhao
contact affiliation	Nanyang Technological University
contact email	zhaoyanli@ntu.edu.sg
lab head
Jiawei Liu
contact affiliation	Nanyang Technological University
contact email	liujiaweijaven@126.com
dataset submitter

iProX dataset URI