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PXD036940-1

PXD036940 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleExtracellular matrix educates a tumor macrophage phenotype found in ovarian cancer metastasis
DescriptionRecent studies have shown the tumor extracellular matrix (ECM) associates with immunosuppression, and that targeting the ECM can improve immune infiltration and immunotherapy response. A question that remains is whether the ECM is directly educating the immune phenotypes seen in cancer. We identified a tumor-associated macrophage (TAM) population correlated with poor prognosis, interruption of the cancer immunity cycle, and tumor ECM composition. To investigate whether ECM was capable of generating the TAM phenotype seen, we developed a decellularized tissue model that retains the native ECM architecture and composition. Macrophages cultured on decellularized ovarian metastasis shared transcriptional profiles with the TAMs found in human tissues. ECM educated macrophages have a tissue remodeling and immunoregulatory phenotype, inducing altered T cell function. We conclude that the tumor ECM is directly educating this macrophage population found in cancer tissues. Therefore, current and emerging cancer therapies that target the tumor ECM may be tailored to improve macrophage phenotype and their downstream regulation of immunity.
HostingRepositoryPRIDE
AnnounceDate2023-04-11
AnnouncementXMLSubmission_2023-04-11_05:43:04.912.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD036940
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterVinothiniRajeeve
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-09-22 00:12:51ID requested
12023-04-11 05:43:05announced
22023-11-14 09:01:08announced2023-11-14: Updated project metadata.
Publication List
Keyword List
submitter keyword: cancer, Tumor-associated macrophages, proteomics,Decellularized tissue model, immunity, extracellular matrix, LC-MS/MS
Contact List
Professor Pedro RCutillas
contact affiliationProfessor of Cell Signalling & Proteomics Centre for Genomics and Computational Biology Barts Cancer Institute Queen Mary, University of London John Vane Science Centre, Charterhouse Square, London EC1M 6BQ Tel: +44 (0)20 7882 8266 | Fax: +44 (0)20 7882 3891
contact emailp.cutillas@qmul.ac.uk
lab head
VinothiniRajeeve
contact affiliationCentre for Haemato Oncology
contact emailv.rajeeve@qmul.ac.uk
dataset submitter
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Dataset FTP location
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