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PXD036900-2

PXD036900 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleBiomarkers found in the tumor interstitial fluid may help explain the differential behavior among keratinocyte carcinomas
DescriptionKeratinocyte carcinomas (KC) are the most common malignancy worldwide. This category of tumours groups both basal (BCC) and squamous (SCC) cell carcinomas. While the former rarely metastasizes (0.03-0.55%), the latter is more associated to a substantial risk of local recurrence, metastasis and death (1.5-4%). In addition, it is well known that the extracellular signals from tumour cells are involved in most of the steps triggering metastasis. This pro-metastatic signalling is mediated by proteins secreted by cancer cells, which constitute the tumour secretome and can be obtained from tumour interstitial fluid (TIF). The TIF baths the tumour and stromal cells and characterizes the tumour microenvironment. The proteomic study of TIF is of particular interest for explaining the metastatic potential of a tumour. In this work, we have analysed the proteomic composition of the TIF from BCC and SCC tumour biopsies and discovered a new set of extracellular proteins that could be useful as differential biomarkers. In addition, these proteins may help to understand the distinct invasive and metastatic abilities of the KC.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:58:51.939.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJoan Josep Bech-Serra
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-09-21 09:38:40ID requested
12023-04-14 06:21:20announced
22023-11-14 08:58:52announced2023-11-14: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: orbitrap dusion lumos,basal cell carcinoma, squamous cell carcinoma, tumor interstitial fluid, label free
Contact List
Eloi Gari
contact affiliationCell Cycle, Department of Basic Medical Sciences, Institut de Recerca Biomèdica de Lleida (IRBLLEIDA), University of Lleida, Lleida, Spain.
contact emaileloi.gari@udl.cat
lab head
Joan Josep Bech-Serra
contact affiliationProteomics Unit - Josep Carreras Leukaemia Research Institute
contact emailjbech@carrerasresearch.org
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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