PXD036844-1
PXD036844 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic landscape of plasma and plasma-derived sEVs and lEVs in uveitis and posterior scleritis |
Description | Uveitis and posterior scleritis are sight-threatening diseases with undefined pathogenesis, accurate diagnosis remains challenging. Here, two plasma-derived extracellular vesicle (EV) subpopulations, small and large EVs, were obtained from patients with uveitis and posterior scleritis and subjected to proteomics analysis alongside plasma. We identify 3,658 proteins, with 3,097, 3,312, and 2,820 quantifiable proteins for sEVs, lEVs, and plasma, respectively. The proteomes of the two EV subgroups differed significantly and were more highly correlated with disease development than that of plasma. Comprehensive bioinformatics analysis of the EVs and plasma highlighted a potential pathogenic mechanism for these diseases. Four potential biomarker panels for four diseases were identified and validated. We found a negative correlation between plasma endothelin-converting enzyme 1 levels and mean retinal thickness. This study provides a proteomic landscape of the molecular changes in plasma and EVs involved in four diseases, offers insights into their potential pathogenesis, and identifies valuable biomarker candidates. |
HostingRepository | iProX |
AnnounceDate | 2022-09-19 |
AnnouncementXML | Submission_2022-09-19_01:29:36.677.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Lingzi Wu |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | TripleTOF 6600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2022-09-19 01:29:05 | ID requested | |
⏵ 1 | 2022-09-19 01:29:37 | announced | |
2 | 2023-06-25 20:04:10 | announced | 2023-06-26: Update publication information. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: uveitis, posterior scleritis, plasma, small extracellular vesicles, large extracellular vesicles, proteomic profiles, biomarkers |
Contact List
Xiaomin Zhang | |
---|---|
contact affiliation | Tianjin Medical University Eye Hospital |
contact email | xzhang08@tmu.edu.cn |
lab head | |
Lingzi Wu | |
contact affiliation | Tianjin Medical University Eye Hospital |
contact email | wlz_5206@tmu.edu.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |