<<< Full experiment listing

PXD036782-2

PXD036782 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDLST mutations in pheochromocytoma and paraganglioma cause proteome hyposuccinylation and metabolic remodeling
DescriptionUsing stable cell lines, we found that succinylation levels were highly dependent on DLST. Furthermore, PPGL-causing DLST mutations, predicted to alter DLST homo-oligomeric complex structure, caused a significant remodeling of the cellular succinylome. Succinylation is thought to cause major chemical and structural changes in proteins, most likely influencing their function. Accordingly, we found that the dysregulation of succinylation appeared to influence several essential pathways related to PPGL development such as hypoxia, glycolysis and oxidative phosphorylation. This study points to succinylation as a new mechanism involved in the development of PPGLs, supporting the growing body of research highlighting the role of this PTM in different types of cancer.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:59:04.764.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterFernando Garcia
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListsuccinylated residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-09-17 02:40:51ID requested
12023-05-04 03:24:44announced
22023-11-14 08:59:05announced2023-11-14: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: DLST
succinylation
pheochromocytoma
paraganglioma
Contact List
Fernando Garcia Martinez
contact affiliationFernando Garcia Martinez Ph.D. Proteomics & MS Specialist Proteomics Unit, Spanish National Cancer Research Centre (CNIO) Melchor Fernández Almagro 3. E28029 MADRID, SPAIN. Phone +34 912246900 ext 3112
contact emailfgarcia@cnio.es
lab head
Fernando Garcia
contact affiliationFernando García Martínez, Ph.D. Proteomics Unit, Spanish National cancer Research Center, CNIO, MADRID, SPAIN
contact emailfgarcia@cnio.es
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/05/PXD036782
PRIDE project URI
Repository Record List
[ + ]