PXD036571 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | COVID-19 salivary protein profile: unravelling molecular aspects of SARS-COV-2 infection |
Description | COVID-19 is the most impacting global pandemic of all times with over 600 million infected and 6.5 million deaths worldwide, in addition to an unprecedented economic impact. Despite the many advances in scientific knowledge about the disease, much remains to be clarified about the molecular alterations induced by SARS-COV-2 infection. For this reason, it is urgent to carry out studies that help to clarify the molecular changes after SARS-COV-2 infection. In this work, we show a hybrid proteomics and in silico interactomics strategy to establish a COVID-19 salivary protein profile. The differential proteome was narrowed down by PLS-DA tool and the enrichment analysis was performed with FunRich. In parallel OralInt was used to determine interspecies PPIs between humans and SARS-CoV-2. Five dysregulated biological processes were identified in COVID-19 proteome profile: Apoptosis, Energy Pathways, Immune Response, Protein Metabolism and Transport. Interactomics analysis allowed the identification of new PPIs between the virus and the host, representing molecular aspects that could be important to understand this disease. |
HostingRepository | PRIDE |
AnnounceDate | 2023-03-11 |
AnnouncementXML | Submission_2023-03-10_18:33:28.868.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | VeraMendes |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | S-carboxamidoethyl-L-cysteine |
Instrument | TripleTOF 6600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-09-08 06:50:34 | ID requested | |
⏵ 1 | 2023-03-10 18:33:29 | announced | |
2 | 2023-11-14 08:27:58 | announced | 2023-11-14: Updated project metadata. |
Publication List
Esteves E, Mendes VM, Manadas B, Lopes R, Bernardino L, Correia MJ, Barros M, Esteves AC, Rosa N, COVID-19 Salivary Protein Profile: Unravelling Molecular Aspects of SARS-CoV-2 Infection. J Clin Med, 11(19):(2022) [pubmed] |
Keyword List
ProteomeXchange project tag: Sars-cov-2, Covid-19 |
submitter keyword: COVID-19 |
Saliva |
Proteomics |
Interactomics |
OralInt |
Contact List
NunoRosa |
contact affiliation | Universidade Católica Portuguesa, Faculty of Dental Medicine (FMD), Center for Interdisciplinary Research in Health (CIIS) Portugal |
contact email | nrosa@ucp.pt |
lab head | |
VeraMendes |
contact affiliation | Center for Neuroscience and Cell Biology, University of Coimbra |
contact email | vera3m@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD036571
- Label: PRIDE project
- Name: COVID-19 salivary protein profile: unravelling molecular aspects of SARS-COV-2 infection