PXD036571

PXD036571 is an original dataset announced via ProteomeXchange.

Title	COVID-19 salivary protein profile: unravelling molecular aspects of SARS-COV-2 infection
Description	COVID-19 is the most impacting global pandemic of all times with over 600 million infected and 6.5 million deaths worldwide, in addition to an unprecedented economic impact. Despite the many advances in scientific knowledge about the disease, much remains to be clarified about the molecular alterations induced by SARS-COV-2 infection. For this reason, it is urgent to carry out studies that help to clarify the molecular changes after SARS-COV-2 infection. In this work, we show a hybrid proteomics and in silico interactomics strategy to establish a COVID-19 salivary protein profile. The differential proteome was narrowed down by PLS-DA tool and the enrichment analysis was performed with FunRich. In parallel OralInt was used to determine interspecies PPIs between humans and SARS-CoV-2. Five dysregulated biological processes were identified in COVID-19 proteome profile: Apoptosis, Energy Pathways, Immune Response, Protein Metabolism and Transport. Interactomics analysis allowed the identification of new PPIs between the virus and the host, representing molecular aspects that could be important to understand this disease.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:27:57.501.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Vera Mendes
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	S-carboxamidoethyl-L-cysteine
Instrument	TripleTOF 6600

Revision	Datetime	Status	ChangeLog Entry
0	2022-09-08 06:50:34	ID requested
1	2023-03-10 18:33:29	announced
⏵ 2	2023-11-14 08:27:58	announced	2023-11-14: Updated project metadata.

Esteves E, Mendes VM, Manadas B, Lopes R, Bernardino L, Correia MJ, Barros M, Esteves AC, Rosa N, COVID-19 Salivary Protein Profile: Unravelling Molecular Aspects of SARS-CoV-2 Infection. J Clin Med, 11(19):(2022) [pubmed]

ProteomeXchange project tag: Sars-cov-2, Covid-19

submitter keyword: COVID-19

Saliva

Proteomics

Interactomics

OralInt

Nuno Rosa
contact affiliation	Universidade Católica Portuguesa, Faculty of Dental Medicine (FMD), Center for Interdisciplinary Research in Health (CIIS) Portugal
contact email	nrosa@ucp.pt
lab head
Vera Mendes
contact affiliation	Center for Neuroscience and Cell Biology, University of Coimbra
contact email	vera3m@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD036571

PRIDE project URI

• PRIDE
  1. PXD036571
     1. Label: PRIDE project
     2. Name: COVID-19 salivary protein profile: unravelling molecular aspects of SARS-COV-2 infection