⮝ Full datasets listing
PXD036544-1
PXD036544 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic analysis of Adnp mutant mice |
| Description | We report age-differential synaptic plasticity deficits associated with cognitive inflexibility and CaMKIIa hyperactivity in Adnp-mutant mice. These mice show impaired and inflexible contextual learning and memory additional to social and anxiety-related deficits in adults long after a marked decrease in ADNP protein levels to ~10% of newborn levels in juveniles. In addition, Adnp-mutant adults show abnormally enhanced long-term potentiation in adults but not in juveniles. This accompanies CaMKIIa hyperactivity involving increased baseline autophosphorylation, as revealed by unbiased proteomic analyses. |
| HostingRepository | MassIVE |
| AnnounceDate | 2023-07-11 |
| AnnouncementXML | Submission_2023-07-11_04:52:46.232.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Heeyoun Hwang |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | Oxidation; Carbamidomethyl |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-09-05 19:09:07 | ID requested | |
| ⏵ 1 | 2023-07-11 04:52:46 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: ADNP syndrome, Autism spectrum disorders, LC-MS/MS, Cognitive inflexibility |
Contact List
| Jin Young Kim | |
|---|---|
| contact affiliation | Korea Basic Science Institute |
| contact email | jinyoung@kbsi.re.kr |
| lab head | |
| Heeyoun Hwang | |
| contact affiliation | KBSI |
| contact email | heeyounh@kbsi.re.kr |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000090257/ |
